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Sporadic cases of hyperpyrexia and confusion have been associated with dose reductions and withdrawal of SINEMET or SINEMET CR.
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Until more research is performed, this drug-nutrient combination must be viewed as preliminary.
This is accounted for by the possible differences in their inactive ingredients such as color and flavor additives, and by the copyright and trademark regulations that does not allow for exact copies of the existing brand-name products.
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Therapeutic use in Parkinson's disease is effective because of the drug's strong dopaminergic action.
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When levodopa is administered orally it is rapidly decarboxylated to dopamine in extracerebral tissues so that only a small portion of a given dose is transported unchanged to the central nervous system.
The VIM nucleus is considered the best target for tremor suppression, with excellent short- and long-term tremor suppression in 80-90% of patients with Parkinson disease.
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On 12 August 2010, Lilly lost a lawsuit that challenged its patent on Strattera, increasing the likelihood of an earlier entry of a generic into the US market.